The FMI has established a chiral analytical and semi-preparative chromatography hub. Utilising the SFC system recently installed in the FMI, we have recently acquired a range of chiral analytical columns, that cover a broad range of stationary phases, to carry out a systematic screening program with the aim of identifying methods for separating mixtures of enantiomers. This system can be used to:

1. carry out standard analytical screening to support chiral chemistry project – determination of %ee

2. identify chiral separation methods for scaling up to semi-preparative chromatography

For accessing the analytical technologies, please contact FMI@qub.ac.uk. Ideally samples should be submitted as a dry powder (3-5 mg) for chiral method development and less than 1 mg for analysis of samples with pre-established screening.

For preparative separation, once an analytical method is identified from the chiral screening, we will acquire a semi-preparative column upon agreement of a body of work with the collaborator to carry out purifying racemic materials (10 mg to 1 g). Prices for the separation services will be agreed between the FMI and collaborator prior to work commencing. All final purified materials will be concentrated to dryness for supplying to the collaborator with a full analytical check (chiral and standard analytical column) to ensure purity.