Chemical Biology
Our Services
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•Synthesis of core intermediate on 1-3 g scale (ease of synthesis)
•Library small molecule chemistry carried out on 10-50 mg scale
•Initial small molecule library will contain ‘hit’ and diverse analogues to explore SAR
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•Post reaction work-up carried out using solid phase reagents
•All compounds have LC-MS checks to determine reaction success and purification requirements
•All compounds requiring purification are carried out via preparative HPLC/SFC
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•In house electronic notebook and compound registration systems in place
•Individual projects ring-fenced and firewalled to protect information
•All final compounds accurately weighed, barcoded and tracked
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Description text goes hereAll compounds screened in desired biological assays (biochemical and/or cell based)
•Data generated used to inform next iteration of compound library generation
•Off-target screening
•In addition, rounds of more focussed libraries, such as solubility, stability, cLogP (partner)
Capabilities
Located in the Patrick G Johnston Centre for Cancer Research (PGJCCR), gain access to our chemical biology team that has extensive research in developing potent and selective compounds.
•Technology Enabled Synthesis or TES is a medicinal chemistry platform that allows for rapid SAR (Structure Activity Relationship) during the ‘Hit validation’ and early ‘Hit to lead’ programmes
•Using cutting edge technologies, we can carry out early-stage drug development work in a pre-competitive environment
Team
Dr Rich Williams
Academic Lead
Small molecule inhibitor development/ protease biology
Robert Haydon
Research Technician
Process scale-up, chemical analysis
Dr. Emma Clyde Allen
Research Fellow
Small molecule inhibitor development/ protease biology
Dr Benjamin Owen
Research Fellow
Drug development
Our technology
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ISOLUTE® Single Fritted Columns
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![Medical laboratory machine for blood processing with a digital screen, test tubes, and connected tubing.]()
Biotage Isolera System
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![Laboratory instrument named CLARIOstar Plus with BMG LABTECH branding, used for scientific analysis or experiments.]()
CLARIOstar Plus
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![Medical laboratory machine with test tubes, a monitor displaying graph data, and various apparatus for blood analysis.]()
Teledyne ACCQ Prep HP150 HPLC
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![A tall stack of household appliances including a washing machine, several microwave ovens, a dishwasher, and a refrigerator, arranged vertically.]()
Agilent Single Quadrupole LC/MS
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![Laboratory machine with a digital screen, bottles, and tubing inside, used for scientific or medical testing.]()
Sepiatec preparative HPLC system
Description goes here -
![Laboratory instrument with a circular black lid and a touchscreen display, featuring a blue liquid container or chamber.]()
Genevac EZ-2 40 Series Centrifugal Evaporator
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![A biohazard laboratory machine with small vials and gold coins on top and a display screen on the front.]()
Monowave 450
Visit us
The Patrick G. Johnston Centre for Cancer Research 97 Lisburn Rd, Belfast BT9 7AE
Hours
Monday–Friday
8am–5pm
Email rich.wiliams@qub.ac.uk